The 2025 MLB season has officially kicked off, featuring 28 of the 30 MLB teams on Opening Day. Highlighting the event are the Los Angeles Dodgers and New York Yankees, last year's World Series participants. Notably, Lars Nootbaar stands out as the only USC alum on an active MLB roster, having played 109 games for the St. Louis Cardinals in 2024. Garrett Stubbs, previously the No. 2 catcher for the Philadelphia Phillies, has been optioned to Triple-A. Other former Trojans like Kyle Hurt and Tyler Gilbert are sidelined with injuries, while Blake Sabol starts the season in Triple-A with the Boston Red Sox.

The roster also features notable coaches from USC, including Yankees manager Aaron Boone and Dodgers pitching coach Mark Prior, emphasizing USC's lasting impact in Major League Baseball.